AMU Develops New method for detection of multi-drug resistant NDM-Super bug

Interdisciplinary Biotechnology Lab at Aligarh Muslim University has developed easy method for the detection of multi-drug resistant NDM-Super bug, said,Dr. Asad Ullah Khan, Associate Professor, Interdisciplinary Biotechnology Unit, AMU.

Dr. Khan said that the major cause of developing drug resistance against different classes of antibiotics is widespread antibiotic usage which may provide a selective force for antibiotic resistant bacteria. Recently, clinical isolates from different sites have been screened for the presence of NDM-1 in the laboratory. Dr. Khan's group has already identified NDM-1 by PCR based detection method in many clinical isolates of different sites and he has established easy detection method in his laboratory. The work on NDM-1 and its other 3 variants has already been started in Dr Khan's laboratory. Dr. Khan has already sequenced the gene and working on the genetics of this gene.

He said that the emergence of NDM-1 in India heralded a new era of multi drug resistance. The NDM-1 carrying bugs are resistant against all antibiotics apart from tigecyclin and colistin and therefore it is difficult to fight with infection caused by NDM-superbug.

According to Dr Khan NDM-1 was first identified in December 2009 in New Delhi, India. New Delhi Metallo-beta-lactamase, commonly known as “NDM-1”, is a gene that makes bacteria resistant to beta-lactam antibiotics. Beta-lactam antibiotics are utilized to treat antibiotic resistant bacteria. Bacteria that are resistant to drug treatment are referred to as “Superbugs”. Superbugs may create dangerous infections which are nearly impossible to treat, and resistant to antibiotics. The antibiotic resistance of the NDM1 gene may exponentially accelerate the spread of bacteria that carry it through humans. NDM1 has been detected in bacteria in India, Pakistan, the United States, and the United Kingdom. Currently, NDM1 has been hosted by E.coli bacterium and Klebsiella pneumonia.

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